Regulatory Mechanisms of TRAF2-mediated Signal Transduction by Bcl10, a MALT Lymphoma-associated Protein

Molecular Mechanisms of Bcl 10 - Mediated NF - kappaB Signal Transduction

Signal Transduction by Immunoglobulin Is Mediated

Immunoglobulin (Ig) antigen receptors are composed of a noncovalently-associated complex of Ig and two other proteins, Igo~ and Ig3. The cytoplasmic domain of both of these Ig associated proteins contains a consensus sequence that is shared with the signaling proteins of the T cell and Fc receptor. To test the idea that Igc~-IgB heterodimers are the signaling components of the Ig receptor, we h...

Signal Transduction by Immunoglobulin Is Mediated Through

Immunoglobulin (Ig) antigen receptors are composed of a noncovalently-associated complex of Ig and two other proteins, Igo~ and Ig3. The cytoplasmic domain of both of these Ig associated proteins contains a consensus sequence that is shared with the signaling proteins of the T cell and Fc receptor. To test the idea that Igc~-IgB heterodimers are the signaling components of the Ig receptor, we h...

Mechanisms of Cellular Signal Transduction

Editorial Signal transduction is essential for almost all aspects of eukaryotic cell function and for the development of metazoans. In the classic case of signaling mediated by a growth factor, binding of the hormone to its receptor initiates a process that starts with the autoor cross-phosphorylation of the receptor. The activating signal is then propagated through intracellular signaling path...

AKAP mediated signal transduction.

Compartmentalization of cyclic AMP-dependent protein kinase (PKA) is achieved through association with A-kinase anchoring proteins (AKAPs). AKAPs are a group of structurally diverse proteins with the common function of binding to the regulatory subunit of PKA and confining the holoenzyme to discrete locations within the cell. This mode of regulation ensures that PKA is exposed to isolated cAMP ...